Detailed view for LOAG_11033

Basic information

TDR Targets ID: 935811
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 5.6553 | Length (AA): 101 | MW (Da): 10924 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 85 1r5m (A) 213 297 20.00 0.5 0.35 1.02108 -0.21
9 78 4wju (A) 405 473 14.00 0.012 0.03 0.811169 -0.02
9 100 5nuv (A) 325 421 24.00 0.13 0.04 1.05199 0.36

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129368)

Species Accession Gene Product
Arabidopsis thaliana AT4G29380   phosphoinositide-3-kinase, regulatory subunit 4, p150
Brugia malayi Bm1_22785   Protein kinase domain containing protein
Candida albicans CaO19.7773   similar to S. cerevisiae VPS15 (YBR097W)
Candida albicans CaO19.7776   similar to N terminal half of VPS15 protein kinase involved in vacuolar protein sorting
Candida albicans CaO19.7775   similar to S. cerevisiae VPS15 (YBR097W)
Candida albicans CaO19.130   similar to N terminal half of VPS15 protein kinase involved in vacuolar protein sorting
Candida albicans CaO19.129   similar to S. cerevisiae VPS15 (YBR097W)
Caenorhabditis elegans CELE_ZK930.1   Protein ZK930.1, isoform B
Dictyostelium discoideum DDB_G0282627   VPS15 family protein kinase
Drosophila melanogaster Dmel_CG9746   immune response deficient 1
Echinococcus granulosus EgrG_000725500   phosphoinositide 3 kinase regulatory subunit 4
Entamoeba histolytica EHI_044190   protein kinase with WD repeats
Echinococcus multilocularis EmuJ_000725500   phosphoinositide 3 kinase regulatory subunit 4
Homo sapiens ENSG00000196455   phosphoinositide-3-kinase, regulatory subunit 4
Loa Loa (eye worm) LOAG_03673   VPS15 protein kinase
Loa Loa (eye worm) LOAG_11033   hypothetical protein
Mus musculus ENSMUSG00000032571   phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150
Oryza sativa 4331010   Os02g0796700
Saccharomyces cerevisiae YBR097W   Vps15p
Schistosoma japonicum Sjp_0032570   Phosphoinositide 3-kinase regulatory subunit 4, putative
Schistosoma japonicum Sjp_0032530   ko:K08333 phosphoinositide-3-kinase, regulatory subunit 4, p150, putative
Schistosoma mansoni Smp_123610   serine/threonine protein kinase
Schmidtea mediterranea mk4.001936.06  
Schmidtea mediterranea mk4.001936.03   Phosphoinositide 3-kinase regulatory subunit 4
Schmidtea mediterranea mk4.001936.02   Serine/threonine kinase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens phosphoinositide-3-kinase, regulatory subunit 4 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_11033 (Loa Loa (eye worm)), hypothetical protein
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